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Don't Replace your testosterone, restore it with Enclomophine.

Enclomiphene is a selective estrogen receptor modulator that stimulates your body’s own testosterone production through the HPG axis. Unlike exogenous TRT, it raises testosterone by restoring the hormonal signal — keeping LH, FSH, and sperm production intact. Oral daily dosing.

Oral daily dosing, no injections, no gels, no topical transfer risk

Preserves sperm count — unlike exogenous TRT

Supports endogenous testosterone production via LH/FSH stimulation

Physician-prescribed and clinically monitored

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You didn’t loose your edge.Your Hormones Lost Their Signal.

After 30, testosterone declines 1–2% per year. But for most men, the problem isn't that the testes stopped working ,it's that the signal from the brain slowed down. Secondary hypogonadism means your hypothalamus and pituitary aren't sending enough LH and FSH to drive testosterone production. The factory works fine. The work order stopped coming in.

Enclomiphene is a selective estrogen receptor modulator (SERM) — the purified, active isomer of clomiphene citrate. It blocks estrogen feedback at the hypothalamus, which restarts the signaling cascade: more GnRH → more LH and FSH → more testosterone. Produced by your own body.

This isn't replacement. It's restoration.

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THE DIFFERENCE

Exogenous testosterone (TRT) raises your T levels, but shuts down LH, FSH, and sperm production. Enclomiphene raises your T levels by turning the signal back on — keeping your entire hormonal axis intact.

TESTOSTERONE INCREASE

Baseline → 16 Weeks Enclomiphene raised total testosterone into the normal range while maintaining LH and FSH levels. Testosterone gel achieved similar T levels but suppressed LH and FSH.

*Two Phase III RCTs (ZA-304 & ZA-305), overweight men aged 18–60 with secondary hypogonadism. Kim et al., BJU Int, 2016.

SPERM PRESERVATION

Enclomiphene maintained sperm concentrations in the normal range throughout 16 weeks of treatment. Men on testosterone gel saw declining sperm counts, many reaching the lower limit of normal.

*Same Phase III RCTs. Kim et al., BJU Int, 2016.

Testosterone Is Just the Beginning. Your body starts producing more—naturally.

Enclomiphene works with your body, not against it. Instead of replacing testosterone, it stimulates your natural production through the HPG axis. In clinical studies, men saw meaningful increases in total testosterone in as little as 14 days, without shutting down fertility or long-term hormonal function.

DOSE-DEPENDENT T RESPONSE

After 14 days of oral dosing:

12.5 mg/day → mean TT of 412 ng/dL 
25 mg/day → mean TT of 520 ng/dL 
50 mg/day → mean TT of 589 ng/dL
(Baseline mean: 275 ng/dL)

Phase II RCT, N=52. Kaminetsky et al., J Sex Med, 2013.

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META-ANALYSIS: SERM EFFICACY SERM therapy (clomiphene/enclomiphene) increased total testosterone by an average of +273.76 ng/dL vs. placebo (p < 0.01) across 10 randomized controlled trials.

Hohl et al., Arch Endocrinol Metab, 2025. Systematic review & meta-analysis of 10 RCTs.

How Relm Works

Concierge-level care from home — physician-guided, evidence-based, built around you.

Step 1

Test From Home

We ship a comprehensive blood panel straight to your door. Collect your sample in minutes — no clinic visit, no appointment, no hassle. Ship it back in the prepaid mailer and your results go directly to your physician.

Step 2

Meet Your Doctor

A licensed physician personally reviews your full panel and meets with you to discuss what your numbers mean, what’s working, and what isn’t. No rushed 5-minute appointments. No generic advice.

Step 3

Get Your Plan

Based on your bloodwork and consultation, your physician builds a personalized protocol whether that’s a prescription, lifestyle recommendations, or ongoing monitoring. Your treatment ships to your door, often within days.

Physician-led. Evidence-based. Built around you. 

All treatments require a physician evaluation and prescription. Not available in all states. Individual results may vary.

Here's Why People Switch to Relm

Everything you’d expect from a concierge doctor, without the waiting room,
the referral chain or the $500 office visit.

Physician personally reviews your full panel

Personalized protocol, not one-size-fits-all

Treatment shipped directly to your door

No in-office visits required

Straightforward pricing, no surprise bills

Access to physician via messaging

Appointments that fit your schedule

Licensed, board-eligible physicians

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Frequently Asked Questions

Have another question? Please contact our team!

How does enclomiphene increase testosterone naturally? +

Enclomiphene blocks estrogen receptors at the hypothalamus, which removes the negative feedback loop that suppresses GnRH release. This allows LH and FSH to rise, signaling the testes to produce more testosterone endogenously. The hormone your body makes is its own — not introduced externally.

What should I expect from enclomiphene treatment? +

Clinical studies show total testosterone can reach normal levels within fourteen days of daily dosing. Most men notice improvements in energy, mood, and libido within two to four weeks. Full hormonal optimization typically develops over eight to sixteen weeks as the HPG axis stabilizes.

Is enclomiphene safe for long-term use? +

A retrospective review of clomiphene and enclomiphene use found that over eighty percent of men maintained testosterone above 450 ng/dL for up to seven years, with seventy-eight percent reporting symptom improvement. Reported side effects are generally mild and include headache and hot flashes.

How soon will I see results? +

Testosterone levels can normalize within two weeks of starting daily enclomiphene. Symptomatic improvements — energy, mood, libido, body composition — typically become noticeable within two to four weeks. Your physician will confirm progress with follow-up labs at your quarterly check-in.

Will enclomiphene affect my fertility? +

Clinical data shows enclomiphene preserves sperm concentrations in the normal range, unlike testosterone gel which suppresses sperm production. This makes enclomiphene a preferred option for men who want to optimize testosterone without compromising current or future fertility potential.